Your question is exactly about this issue:
Allow instantiating Attribute objects within Twig
Problem/Motivation
Sometimes you have an array of attributes and it would be nice if you could addClass, removeClass, setAttribute, etc. rather than trying to do array manipulation.
Proposed resolution
Add a function to our Twig extension to allow creating an Attribute object from an array of attributes.
Issue: https://www.drupal.org/node/2616756
And the change record for 8.38.3.x:
{% set my_attribute = create_attribute() %}
{%
set my_classes = [
'kittens',
'llamas',
'puppies',
]
%}
<div{{ my_attribute.addClass(my_classes).addAttribute('id', 'myUniqueId') }}>
{{ content }}
</div>
<div{{ create_attribute({'class': ['region', 'region--header']}) }}>
{{ content }}
</div>