You can write try custom Twig_Extention

In yourmodule create service

yourmodule.service.yml

services:
  custom_replace:
    class: Drupal\yourmodule\TwigExtension\Custom_Replace
    arguments: ['@renderer']
    tags:
      - { name: twig.extension }

src/TwigExtension/Custom_Replace.php

<?php

namespace Drupal\user_temp\TwigExtension;

/**
 * Class Custom_Replace.
 */
class Custom_Replace extends \Twig_Extension {


  /**
   * {@inheritdoc}
   */
  public function getName() {
    return 'custom_replace';
  }

  public function getFunctions() {
    return [
      new \Twig_SimpleFunction(
        'custom_replace',
        [$this, 'custom_replace'],
        ['is_safe' => ['html']]
      ),
    ];
  }



  /**
   * {@inheritdoc}
   * @param $search can a array [`word1`,`work2`] or string `word`
   */
  public function custom_replace($string, $search, $replace = '') {
    return str_ireplace($search, $replace, $string);
  }
}

In template yourpage.html.twig

{{ custom_replace('word','',string) }}

You can write try custom Twig_Extention

In yourmodule create service

yourmodule.service.yml

services:
  custom_replace:
    class: Drupal\yourmodule\TwigExtension\Custom_Replace
    arguments: ['@renderer']
    tags:
      - { name: twig.extension }

src/TwigExtension/Custom_Replace.php

<?php

namespace Drupal\yourmodule\TwigExtension;

/**
 * Class Custom_Replace.
 */
class Custom_Replace extends \Twig_Extension {


  /**
   * {@inheritdoc}
   */
  public function getName() {
    return 'custom_replace';
  }

  public function getFunctions() {
    return [
      new \Twig_SimpleFunction(
        'custom_replace',
        [$this, 'custom_replace'],
        ['is_safe' => ['html']]
      ),
    ];
  }



  /**
   * {@inheritdoc}
   * @param $search can a array [`word1`,`work2`] or string `word`
   */
  public function custom_replace($string, $search, $replace = '') {
    return str_ireplace($search, $replace, $string);
  }
}

In template yourpage.html.twig

{{ custom_replace('word','',string) }}

You can write try custom Twig_Extention

You can write try custom Twig_Extention

In yourmodule create service

yourmodule.service.yml

services:
  custom_replace:
    class: Drupal\yourmodule\TwigExtension\Custom_Replace
    arguments: ['@renderer']
    tags:
      - { name: twig.extension }

src/TwigExtension/Custom_Replace.php

<?php

namespace Drupal\user_temp\TwigExtension;

/**
 * Class Custom_Replace.
 */
class Custom_Replace extends \Twig_Extension {


  /**
   * {@inheritdoc}
   */
  public function getName() {
    return 'custom_replace';
  }

  public function getFunctions() {
    return [
      new \Twig_SimpleFunction(
        'custom_replace',
        [$this, 'custom_replace'],
        ['is_safe' => ['html']]
      ),
    ];
  }



  /**
   * {@inheritdoc}
   * @param $search can a array [`word1`,`work2`] or string `word`
   */
  public function custom_replace($string, $search, $replace = '') {
    return str_ireplace($search, $replace, $string);
  }
}

In template yourpage.html.twig

{{ custom_replace('word','',string) }}