After some revise on the template.php, I can theme a node with specific content type. However, could I remove the default region such as header, footer to make it likes a blank page?


I think You need to create specific page.tpl.php for your content and don't include these regions in the template. You name them page--YOUR_CONTENT_TYPE_MACHINE_NAME.tpl.php according to this thread. You can also try this module

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