Yes, it is possible by using db_or() DatabaseCondition as example below:
->fields(array('status' => 1))
Similar for the db_select, see: "OR" condition in db_select() and Nested OR and AND condition with db_select
See also: Multiple conditions for db_update at StackOverflow
You can still use
db_or() as in Drupal 7, but it's deprecated as of Drupal 8.0.x and will be removed in Drupal 9.0.0.
\Drupal\Core\Database\Query\Condition object, specifying an
new Condition('OR'); db_or()