I'm presuming you want to do something like a Facebook Likebox embedded iframe (e.g. https://www.facebook.com/plugins/likebox.php?my_user_facebook_page_details...) with the user supplying his own URL in his user account profile.
If that's the case set up your block view to render your user's URL field with a custom template. Under the Views UI in Advanced > Other > Theme, the Information link will give you a list of template names (e.g. views-view-field--field-my_user_field.tpl.php) that you can put in your theme's template directory and some boilerplate code (found via the link next to the template names). You can alter the template such that the $output
is wrapped in a iframe src
attribute.
Flushing the cache should rebuild everything so that your block's URL field now renders as an iframe on the user page (if you've configured your contextual filter correctly). It probably should be noted that rendering a user-supplied iframe URL is dangerous so you probably should be filtering out non-Facebook URLs.