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For Drupal 7:

Drupal has the function drupal_page_is_cacheable() which can be used to set a page to uncacheable.

Here is the documentation: https://api.drupal.org/api/drupal/includes!bootstrap.inc/function/drupal_page_is_cacheable/7

For Drupal 8:

// Deny any page caching on the current request.    
\Drupal::service('page_cache_kill_switch')->trigger();

Then the code is:

public function myPage() {
  \Drupal::service('page_cache_kill_switch')->trigger();
  return [
    '#markup' => time(),
  ];
}

As usual, clean your cache once done.