Suppose we want to use a different layout/blocks in front page. I know there is a page visibility restriction feature in block configuration, and also Page Manager and Panelsmodules exist, but what's the downside of this solution?

1. Define a specific region content-front in theme
2. Place some blocks in this this region
3. Render this region only in page--front.html.twig template

The above solution has some advantages: front-page blocks are listed separately from other blocks, no need to configure each block to be in <front> page (preventing a O(n) task), using native UI to arrange the blocks.